Androgen receptor gene CAG and GGC repeat lengths in idiopathic male infertility
نویسندگان
چکیده
منابع مشابه
Androgen receptor gene CAG and GGC repeat lengths in idiopathic male infertility.
The androgen receptor (AR) has two polymorphic sites in exon 1, characterized by different numbers of CAG and GGC repeats resulting in variable lengths of polyglutamine and polyglycine stretches. Longer CAG repeats result in a reduced AR transcriptional activity, whereas the role of the GGC triplets is less clear. A relationship between decreased spermatogenesis and moderate expansion in the CA...
متن کاملMale infertility and variation in CAG repeat length in the androgen receptor gene: a meta-analysis.
CONTEXT Many studies have investigated the association between male infertility and trinucleotide repeat polymorphisms in the androgen receptor (AR) gene, but no comprehensive meta-analysis of all published studies has been conducted. OBJECTIVE Our goals were to summarize published data on associations between AR CAG and GGC repeat lengths and male infertility and investigate sources of varia...
متن کاملTrinucleotide (CAG) repeat polymorphisms in the androgen receptor gene: molecular markers of risk for male infertility.
OBJECTIVE To determine whether changes in the polymorphic trinucleotide (CAG) tract of the androgen receptor gene are associated with spermatogenic defects in patients with male infertility. DESIGN Case-control study of two ethnic groups. SETTING University referral centers for male infertility at Baylor College of Medicine, Houston, Texas, and National University Hospital, Singapore. PAR...
متن کاملGenetic Association Between Androgen Receptor Gene CAG Repeat Length Polymorphism and Male Infertility: A Meta-Analysis
The association between polymorphism of androgen receptor gene CAG (AR-CAG) and male infertility in several studies was controversial. Based on studies on association between AR-CAG repeat length and male infertility in recent years, an updated meta-analysis is needed. We aimed to evaluate the association between AR-CAG repeat length and male infertility in advantage of the data in all publishe...
متن کاملAssessment of Correlation between Androgen Receptor CAG Repeat Length and Infertility in Infertile Men Living in Khuzestan, Iran
Background The androgen receptor (AR) gene contains a polymorphic trinucleotide repeat that encodes a polyglutamine tract in its N-terminal transactivation domain (NTAD). We aimed to find a correlation between the length of this polymorphic tract and azoospermia or oligozoospermia in infertile men living in Khuzestan, Iran. MaterialsAndMethods In this case-control study during two years till 20...
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ژورنال
عنوان ژورنال: Molecular Human Reproduction
سال: 2004
ISSN: 1460-2407
DOI: 10.1093/molehr/gah054